We are OPEN following some recent changes to our operation. We have taken the last few weeks to make extensive improvements and facility renovations to help guard against Covid-19 throughout our property. This includes a new UV Sanitizing System installed in all HVAC units to kill all airborne pathogens and contaminants. The Panini's Staff is also committment to the Palmetto Priority Program operating safely under SCDHEC guidelines. Guests are encouraged to join us inside, or on the River Deck overlooking Henry C. Chambers Waterfront Park for lunch, dinner, and drinks.  Read More →

Often called sophisticated, with an old-world grace that charms locals and travelers alike, Downtown Beaufort is a historic destination that sits at the heart of South Carolina’s rich history. The second city to be founded in South Carolina, after Charleston, the Downtown Beaufort area coalesces fascinating Southern history, hospitality, and architecture, with a dash of contemporary glamour. The waterside of Downtown Beaufort are situated alongside several shops and places to explore, but most travelers and locals stroll the sidewalks to find somewhere new and delicious to dine.  Read More →

As the beloved Bubba from Forrest Gump once said, “Shrimp is the fruit of the sea. You can barbecue it, boil it, broil it, bake it, saute it. There's shrimp-kabobs, shrimp creole, shrimp gumbo. Pan fried, stir-fried, and deep fried (shown on a hoagie roll). There's pineapple shrimp, lemon shrimp, coconut shrimp…”...you get the idea. Shrimp is delicious!  Read More →

Take Out, Don't Break Out. Don't let the World around you ruin your appetite! We invite you to order your Panini's favorites TO-GO! Panini's makes it easy for customers to place to-go orders directly from our website or Facebook. Scroll through the menu to find all your Panini's lunch and dinner favorites. Just click or call ahead and leave the cooking to us.   Read More →

We would like to give a special thanks and recognition to Cathryn Miller of Lowcountry Event Services. Cathryn started a local Facebook Group page: Lowcountry Auctions for Bar, Restaurant, and Entertainment Staff out of work due to Covid-19 closures. We're asking for your support today to browse this much needed charity auction.   Read More →

We appreciate our local downtown businesses and understand that lack of staffing can make it difficult to get out for lunch. We are now offering FREE DELIVERY to downtown businesses located from New Castle to Cateret & Bay to Craven from 11am-4pm, Tuesday-Saturday. Call (843) 379-0300.  Read More →

SATURDAY, MARCH 14th at 7PM - If you love great Jazz music, delicious food, and great people, you will definitely not want to miss this Saturday evening as we welcome famous Jazz Guitarist, Howard Paul to Panini’s on the Waterfront. Howard will be a special guest performer with our house Jazz trio lead by ever so talented Vic Varner. Combine fabulous jazz music and wonderful food with an amazing location and view, and you’ve got the perfect evening in downtown Beaufort! Reservations suggested by calling 843-379-0300.  Read More →

Located on a coastal island of South Carolina, the city of Beaufort is home to a notable historical district with no shortage of interesting tourist attractions. The Downtown area, in particular, is an ideal place for locals and tourists to engage in shopping, dining, and entertainment. A visit to Downtown Beaufort is never complete without a stop into Panini’s On The Waterfront. With our convenient Bay Street location, you’ll be able to enjoy shopping and browsing along the way before heading into Panini’s for lunch or dinner. Your dining experience at Panini’s includes exceptional service and the best American/Italian cuisine in Beaufort.   Read More →

From Humble Beginnings to Haute Cuisine, Shrimp and grits has been a Southern staple for centuries – perhaps even millennia. So named for their gritty texture, grits were passed from local native tribes, who ground it from hominy, on to newcomers. The Gullah people of South Carolina’s coastal islands were probably the first to combine grits with the shrimp they caught, and Gullah writings from long ago describe how they savored dishes we would recognize as our modern shrimp and grits.   Read More →

Join us on January 1^st, 2020, 11am to 3pm, to get the New Year started right! We will be hosting our annual old fashioned “Come As You Are” New Year’s Brunch, and we’d love to see you here! Along with our regular menu, we'll have our Breakfast Buffet loaded with all of your favorites for $16.95 per person.   Read More →